非洲猪瘟是由ASFV引起的猪烈性传染病，具有高致死率，自2018年传入我国以来，已造成巨大经济损失，严重威胁全球养猪业安全。由于ASFV基因组庞大复杂，编码蛋白众多，且缺乏有效抗病毒药物和商业化疫苗，其防控一直是全球兽医领域的重大难题。病毒DNA聚合酶作为基因组复制的核心“引擎”，是抗病毒药物开发的关键靶点，但ASFV的DNA聚合酶的复制机制此前尚未被完全解析。

DNA replication is a fundamental process essential for bacterial growth and survival. Initiation begins at the chromosomal origin (oriC), where the conserved initiator protein DnaA assembles into an ...

Non-coding DNA is essential for both humans and trypanosomes, despite the large evolutionary divergence between these two species.

DNA doesn’t just sit still inside our cells — it folds, loops, and rearranges in ways that shape how genes behave.

A new study has illuminated an important process that occurs during cell division and is a likely source of DNA damage under some circumstances, including cancer. A new study from scientists at the ...

A Northwestern Medicine study has revealed a previously unknown connection between two fundamental cellular processes, ...

Changes in genes have been linked to the development of different diseases for a while. However, it's not exactly clear what ...

Researchers at The Institute of Cancer Research, London identified the CIP2A–TOPBP1 complex as a master regulator of DNA repair during mitosis, coordinating backup pathways that protect chromosomes ...

DNA is the molecular basis of heredity, the inherited traits that pass between generations in a person's family tree. Embodied in the sequence of base pairs, DNA carries information between ...