在这项研究中，研究人员表明，DNA断裂在修复后的基因组位点上留下了长期的标记，这破坏了大染色质邻域的三维排列，持续了几轮连续的细胞分裂，并引发了基因表达的遗传性改变，即使原发性DNA损伤被完全修复。该研究将这种现象称为染色质疲劳，并提出它代表了迄今为 ...

Changes in genes have been linked to the development of different diseases for a while. However, it's not exactly clear what ...

Researchers at The Institute of Cancer Research, London identified the CIP2A–TOPBP1 complex as a master regulator of DNA repair during mitosis, coordinating backup pathways that protect chromosomes ...

Genetic mutations which cause a debilitating hereditary kidney disease affecting children and young adults have been fixed in patient-derived kidney cells using a potentially game-changing DNA ...

A large genetic study shows that many people carry DNA sequences that slowly expand as they get older. Common genetic ...

An analysis of genetic data from over 900,000 people shows that certain stretches of DNA, made up of short sequences repeated ...

Jellyfish and anemones sleep to repair neuronal DNA damage Jellyfish and sea anemones extend sleep when neuronal DNA is ...

Dorota Skowronska-Krawczyk sits in her office, eyes fixed on the computer monitor in front of her. "You see it move its eye," ...

Greenland sharks use a unique DNA repair process to protect their eyesight, revealing clues about longevity and retinal preservation.

In jellyfish and sea anemones, neurons accumulate DNA damage while animals are awake and repair that damage during sleep.